αIIBβ3 Integrin Dissociation Induced by EDTA Results in Formation of Birbeck Granule-Like Structures in Human Blood Platelets
نویسندگان
چکیده
منابع مشابه
suppression of coke formation in thermal cracking by coke inhibitors
the main purpose of this research was to:1.develop a coking model for thermal cracking of naphtha.2.study coke inhibition methods using different coke inhibitors.developing a coking model in naphtha cracking reactors requires a suitable model of the thermal cracking reactor based on a reliable kinetic model.to obtain reliable results all these models shall be solved simultaneously.for this pu...
15 صفحه اولCoated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII.
Coated platelets, formed by collagen and thrombin activation, have been characterized in different ways: i) by the formation of a protein coat of α-granular proteins; ii) by exposure of procoagulant phosphatidylserine; or iii) by high fibrinogen binding. Yet, their functional role has remained unclear. Here we used a novel transglutaminase probe, Rhod-A14, to identify a subpopulation of platele...
متن کاملRegulation of proplatelet formation and platelet release by integrin αIIbβ3
word count: 196 Text word count: 3665 Heading: Hematopoiesis Blood First Edition Paper, prepublished online May 2, 2006; DOI 10.1182/blood-2005-11-011957 Copyright © 2006 American Society of Hematology For personal use only. on August 31, 2017. by guest www.bloodjournal.org From
متن کاملOutside-In Signalling Generated by a Constitutively Activated Integrin αIIbβ3 Impairs Proplatelet Formation in Human Megakaryocytes
BACKGROUND The interaction of megakaryocytes with matrix proteins of the osteoblastic and vascular niche is essential for megakaryocyte maturation and proplatelet formation. Fibrinogen is present in the vascular niche and the fibrinogen receptor α(IIb)β(3) is abundantly expressed on megakaryocytes, however the role of the interaction between fibrinogen and α(IIb)β(3) in proplatelet formation in...
متن کاملPlatelet Integrin αIIbβ3 Inhibitor Rescues Progression of Apoptosis in Human Platelets
BACKGROUND Apoptosis plays an important role in the physiology of platelet function. We aimed to detect the effect of the platelet integrin αIIbβ3 inhibitor, tirofiban, on apoptotic events, including mitochondrial inner-membrane potential (ΔΨm), phosphatidylserine (PS) exposure on platelet surface, and the generation of reactive oxygen species (ROS), when washed platelets were stimulated with t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1992
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12668284